Bifidobacterium animalis subsp. lactis BB-12

Introduction

Microbiology
Profile
  • Gram positive
  • Non spore former
  • Lactic acid production
  • Non-motile anaerobic bacteria
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    Bifidobacterium animalis BB-12
    Functions
  • Modulation of intestinal microbiota
  • Improve diarrhea in infants and young children
  • Improve respiratory infections
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    Origin First found in the infant gut.
    Genome GenBank

    Functional Studies

    Clinical Trials or Animal Experiments
    ID Category Subject Title Year
    1 clinical trial infantile colic The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12® in infant colic: A randomised, double blind, placebo-controlled trial 2020
    2 clinical trial infantile colic Efficacy of Bifidobacterium animalis subsp. lactis, BB-12® on infant colic - a randomised, double-blinded, placebo-controlled study 2021
    3 clinical trial antibiotic-associated diarrhea (AAD) Bifidobacterium animalis subsp. lactis BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome 2021
    4 clinical trial modulate gut microbiota, immunity Matrix Effects on the Delivery Efficacy of Bifidobacterium animalis subsp. lactis BB-12 on Fecal Microbiota, Gut Transit Time, and Short-Chain Fatty Acids in Healthy Young Adults 2021
    5 clinical trial immunity Combination of the Probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis, BB-12 Has Limited Effect on Biomarkers of Immunity and Inflammation in Older People Resident in Care Homes: Results From the Probiotics to Reduce Infections iN CarE home reSidentS Randomized, Controlled Trial 2021
    6 clinical trial diarrhoea Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study 2015
    7 clinical trial gestational diabetes mellitus (GDM) Effect of probiotic supplements in women with gestational diabetes mellitus on inflammation and oxidative stress biomarkers: a randomized clinical trial 2018
    8 clinical trial type 2 diabetes (T2D) Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study 2017
    9 clinical trial nonalcoholic fatty liver disease (NAFLD) Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease 2020
    10 clinical trial respiratory tract infections (RTIs) Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy 2010
    11 clinical trial antibiotic-associated diarrhea (AAD) Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial 2019
    12 clinical trial respiratory tract infections (RTIs) Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood 2016
    13 clinical trial oral health Bifidobacterium animalis subsp. lactis BB-12 administration in early childhood: a randomized clinical trial of effects on oral colonization by mutans streptococci and the probiotic 2012
    14 clinical trial upper respiratory tract infections (URTIs) Use of a probiotic mixture containing Bifidobacterium animalis subsp. lactis BB-12 and Enterococcus faecium L3 as prophylaxis to reduce the incidence of acute gastroenteritis and upper respiratory tract infections in children 2021
    15 clinical trial type 1 diabetes (T1D) Effects of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function in children with newly diagnosed type 1 diabetes: protocol of a randomised controlled trial 2017
    16 animal experiment immunity Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization 2019
    17 animal experiment colitis The Administration Matrix Modifies the Beneficial Properties of a Probiotic Mix of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5 2021
    18 animal experiment asthma Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway 2022
    19 animal experiment asthma, inflammation Probiotic Bifidobacterium lactis, anti-oxidant vitamin E/C and anti-inflammatory dha attenuate lung inflammation due to pm2.5 exposure in mice 2019
    20 animal experiment tumour Inhibitory effect of yoghurt and soya yoghurt containing bifidobacteria on the proliferation of Ehrlich ascites tumour cells in vitro and in vivo in a mouse tumour model 2004
    21 animal experiment asthma Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma 2007

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